More and more risk-prediction models, such as BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm), BRCAPRO, and IBIS (International Breast Cancer Intervention Study), consider genetic status (in BRCA1/2 and in other common germline variants associated with a small increase in risk [8, 9]) along with other information, including age, ethnicity, family history, lifestyle, and environmental factors, to assess the risk of an individual developing breast cancer [10]. The gene discussed is BRCA1; the disease is breast carcinoma.