Anti-Sj/ITPR1-IgG titres were extraordinarily high both in the IHC assay (up to 1:15,000) and in the CBA (up to >1:1000) during acute disease in patient 1; after removal of the tumour (and thus of the ectopically presented antigen), CBA titres declined to 1:320 and later 1:100. The gene discussed is ITPR1; the disease is neoplasm.