In contrast, depletion of Kindlin-1 in CRC cells restored the expression of epithelial markers E-cadherin and ZO-1, with marked downregulation of mesenchymal markers FN, Snail, Slug, Twist, MMP-7 and LGR-5 (Figure 3C Right panel). The gene discussed is TJP1; the disease is colorectal carcinoma.