Three weeks (for PC3 (pool of the 3 clones for CT and ERRα respectively) and ACE-1 clones) (Figure 2 (PC3 (A–E), ACE-1 (K–Q)) and six weeks (for PC3c clones) (Figure 2 PC3c (F–J)) after tumor cell injections, radiographs revealed that animals bearing ERRα overexpressing tumors had increased bone lesion surfaces whereas ACE-AF2 tumors had decreased bone lesion surface compared to CT tumors (Figure 2 -PC3 (A–B), (Mann-Whitney, P = 0.011) (bone lesion surface mm2)(E), -PC3c (F-G), (Mann-Whitney, P = 0.0175)(J) -ACE-1 (K–M) (Mann-Whitney, P = 0.0079, P = 0.0304) (Q)). Here, ESRRA is linked to neoplasm.