ESRRA and neoplasm: Since the osteoblastic region is highly stimulated in the PC3c model (Figure 2H, 2I) (see the increased of the %BV/TV: (Mann-Whitney, P = 0.022)), the surface of the tumor (TB/STV) decreased in animals bearing PC3c-ERRα (Figure 2J (Mann-Whitney, P = 0.0023)) (asterisks showing bone formation).