Higher ERRα expression was also observed in primary tumors from CRPC patients who had developed bone metastases compared to androgen-sensitive PCa patients (P < 0.005, (PCa) vs (CRPC bone Mets))(Figure 1B) and (P = 0.0178, (PCa) vs (CRPC who all developed bone metastases)) (Figure 1C). Here, ESRRA is linked to posterior cortical atrophy.