ESRRA and posterior cortical atrophy: To determine whether ERRα is involved in PCa bone lesions, we first assessed ERRα mRNA expression (ESRRA) levels during disease progression by performing a meta-analysis of data from the gene expression omnibus (GEO; GSE69129, GSE21034 and GSE32269) (Figure 1A–1C, Supplementary Table S1) [24, 25, 26].