Regulation of TGFb1 expression by ERRα in PCa cells was also confirmed by the lower levels of TGFb1 expression in ERRα-SiRNA versus control sequences-transfected PC3 cells (Si versus Sc, Figure 7E), in XCT-790 treated PC3-ERRα cells versus DMSO (Figure 7F) and by its stimulation in PC3-ERRα versus PC3-CT SC tumors in vivo (Figure 7G). The gene discussed is ESRRA; the disease is posterior cortical atrophy.