Together with our observation that ERRα expression is higher in CRPC patients with bone metastases than without, and that ERRα in PCa alters molecular signaling in the stroma via the regulation of POSTN expression in infiltrating fibroblasts [10], our data provide new mechanistic insights into ERRα-regulated pathways mediating PCa progression in bone. The gene discussed is ESRRA; the disease is posterior cortical atrophy.