Finally, in line with our pre-clinical models, we found that VEGF-A positively correlated with ERRα expression levels in primary CRPC tumor samples from combined microarray datasets GSE1034, GSE6919 and GSE2269 (n = 140, r = 0.364, P < 0.0001) and in bone metastases (GSE29650, GSE41619 and GSE74685) [34–36] (n = 64, r = 0.646, P < 0.0001) (Table 1; Supplementary Table S1). This evidence concerns the gene ESRRA and neoplasm.