By immunohistochemistry, ERRα (Figure 5A, 5B) and VEGF-A (Figure 5C, 5D) expression was observed in PCa cells and higher in PC3-ERRα-induced bone lesions in vivo (Figure 5B and 5D respectively) compared to PC3-CT lesions (Figure 5A and 5C respectively). The gene discussed is ESRRA; the disease is posterior cortical atrophy.