The stimulatory effect of ERRα on PCa-induced bone lesion surface was confirmed by three-dimensional micro-computed tomographic reconstruction (%BV/TV) (cortical and trabecular bone), with a decrease in bone volume in animals bearing PC3-ERRα and ACE-1-ERRα tumors (%BV/TV, Mann-Whitney, PC3 P = 0.022 and, ACE-1 P = 0.0411) suggesting an increase in bone destruction in both ERRα overexpression models (Figure 2E and 2Q, %BV/TV). This evidence concerns the gene ESRRA and posterior cortical atrophy.