Comparatively, using E-cadherin 1 expression as a distal tubular cell marker, we observed that the quantity of this cell type in NK-derived cultures ranged from 41.4 ± 3% at P3 to 28.2 ± 1.8% at P12 (Fig 3D and 3E), while in CKD-derived cells we observed a range from 37.3 ± 2.8% at P3 and 26.1 ± 1.5% at P12. The gene discussed is CDH1; the disease is chronic kidney disease.