These prognostic factors include immunohistochemical (IHC) profiles (estrogen receptor (ER) status, progesterone receptor (PR) status, human epidermal growth factor receptor 2 (HER2) status and Ki-67 proliferation index) [3,4,5,6], lymph node involvement and histological grade [7] and tumor size [8]. This evidence concerns the gene ESR1 and neoplasm.