Previously, Schlatzer et al. [21] investigated PGRN in urine of 74 patients with type 1 diabetes mellitus and concluded that a panel of three proteins (Tamms-Horsfall glycoprotein, clusterin and human α-1 acid glycoprotein) plus PGRN could be used to predict early signs of DKD [21]. This evidence concerns the gene UMOD and type 1 diabetes mellitus.