GRN and diabetic kidney disease: Serum PGRN was increased in advanced DKD patients compared to the other groups [(70.84 (59.04–83.16) vs. albuminuric DKD cases 57.16 (42.24–67.38), diabetic controls 57.28 (42.08–70.47) and non-diabetic controls 44.54 (41.44–53.32) ng/mL; p<0.001] (Fig 1A).