For HPS, PD patients showed significant activations (p < 0.05, FWE cluster corrected) in parietal inferior lobule (PFcm, PFm, PFop, PFt), parietal operculum/S2 (OP1-4), SMA, mesial cingulate cortex, and in the insula (contralateral: Ig2, Id; ipsilateral: Ig1, Ig2, Id1) (HPSPD > baseline). The gene discussed is ID1; the disease is Parkinson disease.