To understand the clinical relevance of our findings, we used the UCSC Cancer Genome Browser to analyze existing RNA-seq data from 160 GBM samples in the TCGA database.37 After ranking the samples according to expression levels of GPR133, we divided the samples into two groups (80 patients per group): GPR133 low (percentile 1–50, blue) and GPR133 high (percentile 51–100, red) (Figure 6f). The gene discussed is ADGRD1; the disease is glioblastoma.