Axl is the most well studied TAM receptor to date, to which many cell biological roles have been attributed, including cell proliferation, survival, cell adhesion and migration,4 blood clot stabilisation, and regulation of inflammatory cytokines.5, 6 Moreover, Axl has been found to be overexpressed in a variety of cancers.3, 7 Even though Axl does not appear to be an initiator of the oncogenic process, its overexpression has been correlated with poor prognosis, promotion of increased invasiveness, epithelial-to-mesenchymal transition (EMT) and chemoresistance.8, 9. This evidence concerns the gene AXL and cancer.