The results from this study suggest that SUSD2 has tumor-suppressive properties in HGSOC, whereas the results from our previous study investigating the role of SUSD2 in breast cancer suggested that SUSD2 increases tumorigenesis, including angiogenesis.15 Although initially surprising, the contrasting phenotypes of SUSD2 in breast and ovarian cancers could be explained by differences in metastasis mechanisms. Here, SUSD2 is linked to ovarian carcinoma.