In contrast, we observed no significant effect on apoptosis of human bladder cancer 5637 cells but a significantly induced cell cycle arrest at G0/G1 phase in the 5637 cells (Figure 3), followed by downregulation of proteins involved in G0/G1 to S phase progression (CDK2/4/6 and cyclin D1). This evidence concerns the gene CDK2 and urinary bladder cancer.