iNOS/NO expression in cancer cells can activate signaling cascades mediated by proteins such as sGC/cGMP, hypoxia-inducible factor-1α (HIF-1α), epidermal growth factor receptor (EGRF), phosphoinositide-3-kinase/Akt (PI3K/Akt), and extracellular signal-regulated kinases-1/2 (ERK1/2). Here, NOS2 is linked to cancer.