Perhaps the most intriguing aspect of TEX is that they contain a plethora of immunoinhibitory molecules (Figure 2) and, in addition to this suppressive cargo, carry tumor-associated antigens (TAA), costimulatory molecules, major histocompatibility complex (MHC) class I and class II molecules, and intraluminal cytokines, which enable TEX to stimulate or suppress immune cells [23]. Here, TEX46 is linked to neoplasm.