Interaction of Interleukin-1 (IL-1) cytokine family members with their receptors are the initial steps during inflammation and dysregulated production or activity of the various members of these factors has been shown to be associated with severe immune mediated diseases like psoriatic arthritis (PsA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), ankylosing spondylitis (AS), rheumatoid arthritis (RA) and type 1 diabetes (T1DM)14, 15, 16, 17, 18, 19, 20, 21, 22, 23, but little is known about their role in the pathogenesis of clinical uveitis. This evidence concerns the gene IL1A and type 1 diabetes mellitus.