As shown in Fig. 3b, the migration of MHCC-97H cells (Human hepatoma cells) toward M2 supernatants was significantly reduced when the THP-1-derived M2 macrophages were pretreated with fucoidan for 24 h or CCL22 neutralizing Abs were added to the coculture system. This evidence concerns the gene CCL22 and hepatocellular carcinoma.