To examine the specificity of hypoxic MYC and PVT1 regulation, we expanded our analysis to a variety of cells from renal tubular origins (renal cancer cell lines, primary renal tubular cells and immortalized renal tubular cells) and non-tubular origins (immortalized podocytes and non-renal cells) with functional re-expressed or wild-type VHL. Here, VHL is linked to renal carcinoma.