Decreased MKK7 in the PFC and hippocampus (HC) is likely to have a disruptive effect on behaviour in the 5-CSRTT because hippocampal-prefrontal interactions occur in various cognitive and behavioural functions, and disruption of the PFC and HC is consistently implicated in psychiatric disease (reviewed in Sigurdsson and Duvarci 2016). This evidence concerns the gene MAP2K7 and psychiatric disorder.