Frequent and mistaken trips to the reward magazine and strong entrainment to the light stimuli may both be examples of Map2k7+/− mice applying increased salience to some aspects of the task, which is interesting in relation to psychiatric disorders that include cognitive impairment, in particular schizophrenia, because one of the symptoms in patients is applying too much salience to particular, often irrelevant, aspects of the environment (Kapur 2003). The gene discussed is MAP2K7; the disease is schizophrenia.