Experiments conducted on arteries from human volunteers with coronary artery disease and animal experimental model with hypertension, diabetes, or atherosclerosis demonstrated that Nox1, Nox2, and Nox5 stimulate endothelial dysfunction, inflammation, and programmed cell death; however, isoform Nox4 protects the vascular system by increasing bioavailability of nitric oxide and stoppage of cell death pathways [50]. This evidence concerns the gene NOX4 and hypertensive disorder.