In an oral glucose tolerance test performed after 14 weeks on WD (Figure 4), GK+/−ApoE−/− mice showed significant glucose intolerance with 2.3-fold increased AUCglucose (Figure 4(b)) and impaired GSIS with AUCinsulin reduced by 49% and 27% (in males and females, resp). This evidence concerns the gene GK and Glucose intolerance.