Expression levels of the TANC gene family genes TANC1 and TANC2 have been indicated to regulate the density of dendritic spines and excitatory synapses (Han et al., 2010) and diagnostic exome sequencing identified a de novo TANC1 missense variation in one patient with severe intellectual disability (de Ligt et al., 2012). Here, TANC2 is linked to Intellectual disability.