CXCL8 and infection: Both A/E pathogens, EPEC and EHEC infection increased the secretion of IL-8 in a time-dependent manner, but EPEC caused a significantly lower increase of IL-8 secretion; 0.6, 2.7, 10, and 19 ng/ml at 0.5, 1, 2, and 4 h of infection, respectively, while EHEC infection caused increases in 0.7, 8, 15.5, and 24.6 ng/ml at 0.5, 1, 2, and 4 h of infection (Figure 6A).