Glioblastoma is notorious for employing a wide variety of immunosuppressive strategies to disrupt the function of immune cells, lower immunoglobulin levels, and generate a plethora of immunosuppressive processes, involving TGF-beta, IL-10, MHC-I downregulation, T-regs recruitment, and increased expression of PD-L1 (20, 64–68). This evidence concerns the gene IL10 and glioblastoma.