TYMS and colorectal carcinoma: A relatively recent meta-analysis based on results from the QUASAR 2 study concluded that variants TYMS 5VNTR 2R/3R (rs45445694) and TYMS 3UTR 6bp ins-del (rs16430/rs151264360) were found to display significant association with global grade 3+ fluoropyrimidine toxicities in Caucasian patients who received capecitabine adjuvant chemotherapy for stage II/III colorectal carcinoma [8].