The investigators proposed a stepwise progression of thyroid carcinoma characterized by increasing mutational burden with greater frequency of mutation seen in the TERT promoter, TP53, EIF1AX, PIK3CA-AKT-mTOR pathway, SWI/SNF complex, mismatch repair genes, and histone methyltransferases [13]. Here, PIK3CA is linked to thyroid gland carcinoma.