Indeed, recent data revealed that an unexpected crosstalk between NK cells and other cells present in the inflamed niche environment (tumor/infected cells or other immune cells, including DCs and T cells) leads to the de novo surface expression of CCR7 by CD56dim KIR+ NK cells in an IL-18-independent manner (51–54) (Figures 1B,C). The gene discussed is CCR7; the disease is neoplasm.