These cellular interactions allow the establishment of important processes crucial for shaping of adaptive immunity: (a) the “DC editing program” is a process resulting in the selection of DCs with optimal antigen-presenting properties allowing appropriate Th1 responses protective against tumors and infections; (b) the acquisition of CCR7 expression by human KIR+ NK cells allows mature cytolytic NK cells to migrate to lymph nodes and exert antitumor and antiviral activity. The gene discussed is CCR7; the disease is infection.