Taken together, as shown in Figure 5D, we presumed that miR-7 deficiency altered that expression of KLF4, which affected the transduction of related signaling pathway, such as NF-κB, AKT, and ERK, and successively influence on the infiltration of various immune cells and the level of inflammatory cytokines, which ultimately ameliorated the pathologies of LPS-induced ALI. Here, AKT1 is linked to acute respiratory distress syndrome.