CXCR4 and neoplasm: Another CB2 receptor agonist, JWH-105, was found to inhibit tumor growth in a NT2.5-orthotopic mouse model and the MMTV-PyMT model and this observation corresponded to decreased pro-metastatic phospho-CXCR4 and phospho-ERK levels in vivo and in vitro (Nasser et al., 2011).