CNR2 and glioma: Furthermore, CB2 expression was found to be elevated in high grade gliomas (Sánchez et al., 2001; Ellert-Miklaszewska et al., 2007) Hence, a series of informative investigations primarily conducted by the Guzman group, have examined the effects of cannabinoids on glioma cell survival with the goal of assessing the feasibility of developing these agents as novel anti-neoplastics.