The anti-tumor activities of Δ9-THC and JWH-015 in hepatocellular carcinoma cell lines (HepG2 and HuH-7) were mediated by the activation of CB2 receptors followed by increased ceramide, ER-stress, PPAR-γ activity, and eventually the induction of autophagy (Vara et al., 2011, 2013). Here, PPARG is linked to neoplasm.