SCARB1 and cardiovascular disorder: Although SR-BI's contributions to reverse cholesterol transport in cardiovascular diseases have been extensively studied, recent evidence has suggested that cholesterol and its metabolites may play a critical role in cancer progression (Danilo and Frank, 2012; Silvente-Poirot and Poirot, 2012; Simko and Ginter, 2014; Kuzu et al., 2016).