Furthermore, increased serum Nrg4 was significantly associated with reduced risk of MetS (OR: 0.615; 95 % CI, 0.450–0.841; P = 0.002), even after adjusting for age, gender, current smoking, alcohol consumption, physical activity, BMI, systolic BP, fasting glucose, triglycerides and HDL-c; however, such associations of serum Nrg4 were not noted for each component of MetS. This evidence concerns the gene NRG4 and metabolic syndrome.