TNF and rheumatoid arthritis: To address this question, we performed an integrated analysis of the hand, wrist, and axillary LN ultrasonographic (US) characteristics in patients with active disease, exploring prospectively two primary issues: the spectrum of structural and vascular alterations of RA axillary LNs detectable by US; and this spectrum’s relationship with the synovial inflammatory process and clinical phenotype, before and on treatment with tumor necrosis factor (TNF) inhibitors.