TF and glioblastoma: In this context, we showed that the newly developed transferrin (Tf)-targeted self-assembling nanoparticles (NPs) incorporating zoledronic acid (ZOL) allowed the successfully use of ZOL in the treatment of GBM, potentiating its in vitro and in vivo antitumor activity on GBM through the acquisition of ability to cross the BBB [6].