PTGES and glioma: Within the context of our investigations towards the synthesis of quinone derivatives with prospects for therapeutic use, we recently studied the natural compound embelin, a potent dual inhibitor [18] of 5-lipoxigenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES)-1 able to suppress proliferation of human glioma cells and to induce apoptosis by inhibiting XIAP and NF-κB signaling pathway [27–29].