Moreover, another retrospective study about 933 unrelated patients enrolled in Verona heart Study has found that increased concentration of apoCIII is associated with elevated thrombin level in the plasma even after adjustment for other risk factors and apoCIII presents similar correlation with the presence of Factor II (FII) G20210A gene variant, the most important genetic determinant of FII and hereditary risk factor for venous thrombosis [20] (Table 1). Here, APOC3 is linked to Venous thrombosis.