Moreover, high NFE2L2 mRNA expression levels, as defined by the 65th percentile value, remained the strongest independent factor for a reduced risk of relapse in the Cox regression model [HRrelapse 0.4 (0.2–0.9), P = 0.031] (Table 3B), as well as in the subgroup of patients with ER positive tumours [HRrelapse 0.2 (0.1–0.7), P = 0.012] (Table 4B). The gene discussed is NFE2L2; the disease is neoplasm.