NFE2L2 and neoplasm: In the multivariate Cox-regression analysis high NFE2L2 mRNA expression levels have been validated as a marker with independent, predictive value for a reduced risk for disease specific death or death from any cause in the whole cohort [HRdisease specific death 0.8 (0.6–1.0); P = 0.041, HRdeath 0.8 (0.6–1.0); P = 0.023] (Table 3A) and in the ER-positive tumour group [HRdisease specific death 0.6 (0.4–0.9); P = 0.008, HRdeath 0.6 (0.4–0.8); P = 0.001] (Table 4A).