ATP7A and Alzheimer disease: MC-1 immunoreactivity was distinct from that of Alz-50, detecting a highly selective signal in AD cf. Non-AD cases (Fig. 3bi + ii, p < 0.0001) and was enhanced in accordance with grouped Braak stages (Fig. 3biii, p < 0.0001), principally derived from the level of reactivity within the high category (low cf. high: p < 0.001; intermediate cf. high: p < 0.01).