The phospho-specific antibody AT8 recognises tau phosphorylated at serine 199, serine 202 and threonine205 residues (p-ser199/ser202/thr205) [9, 27] and is commonly employed by pathologist for post-mortem confirmation of AD diagnosis and for the staging of tau pathology according to Braak stage. This evidence concerns the gene MAPT and Alzheimer disease.