Here, lateral temporal lobe tissue lysates (Brodmann area 21) from human AD cases and non-AD controls were quantified for phosphorylated, conformationally altered and oligomeric tau species alongside amyloidogenic changes in APP metabolism and levels of total, monomeric, oligomeric and pyro-glutamate (pyro-glu) modified Aβ species. The gene discussed is APP; the disease is Alzheimer disease.