ALB and polycystic ovary syndrome: Mechanism of AGE-RAGE signaling in altering steroidogenesis in PCOS has been studied by Diamanti-Kandarakis et al. [84] in human ovarian granulosa cells (KGN) in which they cultured KGN granulosa cell line with LH alone and LH along with human glycated albumin (HGA, representative of AGEs) for 0–2 h.