They demonstrated that increased production of P4, 17-OHP, and T by PCOS theca cells propagated in long-term culture (with or without forskolin) was due to increased mRNA and protein activity of CYP17A1, CYP11A1, and 3β-HSD but not StAR enzyme (Table 1). Here, CYP11A1 is linked to polycystic ovary syndrome.