Regarding the regulation of C3 gene expression by C/EBPβ, our results are in agreement with previous work showing that C/EBPβ plays an important role in the regulation of C3 expression by IL-1β [73, 74] and also with data from microarray analysis by our laboratory showing that the overexpression of C/EBPβ in neuroblastoma cells and its absence in the mouse hippocampus correlates, respectively, with an increase and a decrease in the amount of C3 transcripts [15, 54]. The gene discussed is IL1B; the disease is neuroblastoma.