Kaplan-Meier survival curve showed for the first time that high expression levels of VPS45, WIPI1, TTC1, GNB5, IGBP1 or KLHL21 gene or low levels of KCNMA1 or FCGRT gene were significantly correlated with low overall survival of HCC patients (Fig. 3). The gene discussed is GNB5; the disease is hepatocellular carcinoma.