MAPT and Parkinson disease: The pathological signature in numerous neurodegenerative diseases are characterized by the accumulation of intracellular or extracellular protein aggregates composed of amyloid fibrils [1], such as senile plaques and neurofibrillary tangle composed of β-amyloid, microtubule associated protein tau in Alzheimer’s disease (AD), and Lewy bodies composed of α-synuclein in Parkinson’s disease (PD).