Indeed, we found that the wt control kidney DNA also exhibited 242 CTXs (Fig. 2b, Additional file 1: Table S1, kidney), thereby further corroborating that widespread genomic rearrangements in G1XP lymphomas are false positive that are not caused by deficiency of XRCC4 and/or p53, instead, by different genetic backgrounds of mouse strains. The gene discussed is XRCC4; the disease is lymphoma.