APC and anemia: Since mutations in the gene coding for APC account for most clinical cases of familial adenomatous polyposis (FAP) and sporadic colonic tumors [5], C57BL/6J-APCMin/+ mouse strains have been established to simulate CRC associated with APC mutation, with multiple intestinal adenomas and complications that resemble clinical CRC cases, including anemia and rectal prolapse [24, 25].