In addition to mutations in the Shp2 gene, other leukemia associated mutations have been described that result in constitutive activity of Shp2, including internal tandem duplication of FLT3 in acute myeloid leukemia (AML) and expression of Bcr-abl in CML [28, 29]. Here, PTPN11 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.