Surprisingly, both the most over and under expressed lncRNAs have not yet been associated with any cancer in reviewing previous researches, however, we did observe the positive correlation between XLOC_007433 which is the most over-expressed in HCC tissues and HLA-DQB1.It is generally acknowledged that human leukocyte antigens (HLA) involved with defending viral infection and carcinogenesis. The gene discussed is HLA-DQB1; the disease is cancer.