The fully processed form of VEGF-C (21 kDa) has a high affinity to both, the VEGF-R3 and VEGF-R2 and was implicated as a critical factor for tumor angiogenesis [43], which might be relevant for the observed angiogenic effects in CAM onplants (Figure 4A and 4B). Here, FLT4 is linked to neoplasm.