As about 50% of high-stage biopsies were taken after a primary chemotherapy and stage IV NB patients frequently relapse despite high-dose chemotherapy we tested the effect of chemotherapeutic drugs used in NB treatment on FOXO3 expression, phosphorylation and subcellular localization (Figures 2B and 2C and Supplementary Figures S1 and S2). Here, FOXO3 is linked to neuroblastoma.