DES and cancer: Whereas 4OHT treatment did not affect tumor growth or tissue architecture in NB15/Ctr cells (Figure 5C), the activation of ectopic FOXO3 in NB15/FOXO3 cells not only impaired tumor growth as shown in Figure 5B, but also completely changed the histology of the cancer tissue: A prominent desmin-staining was visible around large vessels and, dispersed throughout the tumor, many desmin-negative caverns and large areas of extracellular matrix deposition with strongly reduced numbers of tumor cells were also detected (Figure 5C, middle, right pictures).