FOXO3 and invasive ductal breast carcinoma: However, as phosphorylation of FOXO3 at conserved PKB sites (T32, S253, S315) should induce the association of nuclear FOXO3 with 14-3-3 proteins and the export of this complex into the cytoplasm, this finding was somewhat surprising and suggested that similar to studies on invasive ductal breast carcinoma [37] the PKB - FOXO3 axis may be disrupted in high-stage NB.