PYCARD and neoplasm: To differentiate the putative tumor-suppressive role of ASC in the keratinocyte from its tumor-promoting functions as an inflammasome adaptor, mice deficient for the inflammasome adaptor protein ASC exclusively in myeloid cells (ASCf/f-LysM-Cre+) and mice specifically deficient for ASC in keratinocytes (ASCf/fK14-Cre+) were generated.