GC and Epidermal Inclusion Cyst: Although function disturbing polymorphisms of the VDR gene did not associate with the incidence of epidermal cysts, both A/A and A/C SNPs of vitamin D binding protein (GC protein rs4588) involved in vitamin D transport showed higher odds of extra-colonic lesions including epidermal cysts compared to the control (Supplementary Table S3 and Table 2, OR = 4.82 and 1.922 respectively; P < 0.05).