At this time it is not known which region of APC beyond codon 850 is actually responsible for regulation of Hippo/Yap signaling but it is quite plausible that some APC mutants found in FAP patients could regulate both Yap and β-catenin, others only Yap, and others only β-catenin [47]. The gene discussed is APC; the disease is Familial adenomatous polyposis.