Interestingly, while VDR polymorphisms do not associate with either epidermal cysts or desmoid tumors, the Bsm1 Bb SNP of VDR shows a significantly higher risk of other extra-colonic lesions including benign cutaneous symptoms such as fibromas, lipomas and osteomas compared to the control group (Supplementary Table S3 and Table 2, OR = 2.372; P < 0.05). This evidence concerns the gene VDR and osteoma.