Alternatively, considering that N-cadherin drives tumor cell invasion/metastasis by associating with FGFR1 and preventing its endocytosis [28, 29], we hypothesize that pro-N-cadherin promotes FGFR1 signaling more efficiently than does N-cadherin, resulting in increased tumor cell invasion. The gene discussed is FGFR1; the disease is neoplasm.