Association with carcinogenesis-regulated genes seems therefore to be a feature of HBx-mediated H3K9me3 enrichments, however, we also found association of H3K9me3 with metabolic processes, such as genes GAPDHS, GCNT1 and SLC16A3, which to our knowledge has not been reported earlier in HBV-associated HCC. Here, GAPDHS is linked to hepatocellular carcinoma.