We next went on to investigate autophagy in C9ALS/FTD patient-derived iNeurons and found markedly decreased levels of basal autophagy compared to their age and gender matched controls, lending further support to C9orf72 haploinsufficiency as a cause of autophagy deficits and p62/sequestosome-1 pathology in C9ALS/FTD.39 The gene discussed is SQSTM1; the disease is frontotemporal dementia.