That oxytocin exerted neuroprotection in OGD, but not in the OGD/R model is consistent with in vivo evidence, demonstrating that the subsequent reperfusion after ischemia exacerbates neuronal functions and causes massive brain injuries when oxygen-saturated and nutrient-rich blood suddenly returns to the lesion after a period of ischemia11, suggesting that OGD/R is worse than OGD. The gene discussed is OXT; the disease is ischemia.